Assembly of the Sos1–Grb2–Gab1 ternary signaling complex is under allosteric control
نویسندگان
چکیده
منابع مشابه
Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control.
Allostery has evolved as a form of local communication between interacting protein partners allowing them to quickly sense changes in their immediate vicinity in response to external cues. Herein, using isothermal titration calorimetry (ITC) in conjunction with circular dichroism (CD) and macromolecular modeling (MM), we show that the binding of Grb2 adaptor--a key signaling molecule involved i...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2010
ISSN: 0003-9861
DOI: 10.1016/j.abb.2009.12.011